One of my favorite extensions in Chrome was the ability to double click a word and it would give a pop-up with the definition. I have not found any extensions like this for Firefox (at least ones that work).
I've added website as a custom search to achieve what you want:
1. visit your favourite dictionary 2. right click inside search field 3. add new search provider (might be called different) and add keyword 4. now use your keyword inside browser's address bar and type word you're looking for 5. fast way: F6, keyword, definition, enter