On Desktop, many extensions have optional permissions that are not enabled by default but provide additional functionality. For example, SponsorBlock by default can only access data for YouTube and SponsorBlock domains, which is the minimal amount required to work on YouTube. However, an optional permission to access all web data allows functionality on third party frontends like Invidious.
On Android, it is impossible to enable such optional permissions, at least through the browser"s GUI (if there's an about:config hack, please tell me. I'm all ears). Thus, extensions like SponsorBlock are soft-locked into default configurations that only work on the official YouTube domain.
The option to enable optional permissions would be most welcome in a future update.