I think there should be a lot of work done to have the profiles working, like for instance making them native and customizable like in Chrome. I think a lot of us are switching over to FF because of Chrome's latest version that doesn't allow adblockers, but there is so much more that Chrome does better which is making this a difficult transition. I created separate profiles, one for work and one personal, and they both have Ublock Origin, however the filters I create don't sync automatically. The only way to do it is to backup/restore, which is very irritating since I am on the same computer and I shouldn't have to copy/paste or backup/restore.